The San Francisco Giants - this year celebrating 60 years in San Francisco.
I am not including the 49ers since they moved to Santa Clara.
My list with a slant towards the Western Neighborhoods:
The Gold Mirror Italian Restaurant at 18th and Taraval.
Shaws Candy and Ice Cream in West Portal Love their thin mint ice cream as a kid.
Swan Oyster Depot on Polk -- not in the Western Neighborhood but owed since 1946 by the Sancimino Family who once lived down the street from me on 18th Avenue. Their kids went to St. Cecilia's Grammar School.